ANNOUNCEMENTS
The creation of an animal model for burn injury with radiation injury is essential to comprehending the complex effects on different physiological systems and developing treatment approaches in nuclear incidents. The creation of such a model, as well as its impact on the gastrointestinal, respiratory, and hematopoietic systems and lung histological changes, are the main subjects of this investigation. Radiation exposure, burn injuries, or a combination of the two were administered to adult mice. Significant anomalies were found by hematopoietic analysis, including changed white blood cell counts and hemoglobin levels that suggested systemic stress and weakened immune system performance. Assessments of the respiratory system revealed structural damage, elevated inflammation, and reduced lung function. Evaluations of the gastrointestinal tract revealed tissue injury, inflammation, and compromised barrier function, underscoring the susceptibility of the gut to many traumas. Alveolar injury, inflammatory infiltration, and widespread fibrosis were all seen in the lung tissues examined histopathologically. These results highlight the serious and complex effects of burn injuries coupled with radiation on several vital physiological systems. This animal model offers a useful platform for additional research into the underlying mechanisms and the creation of focused therapies to lessen the negative consequences of these injuries.
