ANNOUNCEMENTS
Dengue is a global disease more prominent in tropical regions of the world and is gradually found to be spreading in temperate countries with the increased adaptability of the vector, mosquito, Aedes sp. With the increasing number of cases and fatalities being observed, it is the need of the hour to understand the disease and its consequences. The research thesis here presents a study done on pediatric dengue patients’ (0-14 years) plasma samples that included both primary and secondary infections grouped into dengue infection, dengue with warning signs, and severe dengue. The aim was to characterize the metabolomic profile unique to dengue as well as its severity (mild to moderate).
Gas-chromatography mass spectrometry was utilized to obtain the data. The study emphasized the dysregulation observed in metabolic pathways like inositol metabolism, phosphatidylinositol phosphate metabolism, sphingolipid metabolism, vitamin K metabolism, glycolysis, fatty acid biosynthesis, etc. These findings revealed the important involvement of cellular processes like senescence, apoptosis, cell signalling, proliferation, cellular integrity, etc. in the response to dengue infection. Moreover, ignoring the fact whether the infection is primary or secondary, few salient metabolic pathways have come to light like sphingolipid metabolism, glycolysis and lactose degradation associated with mild and severe dengue infection in pediatric (0-14 years) dengue patients.
Keywords: Dengue, GC-MS TOF, Metabolomics, DENV, Infection.
