This thesis offers an overview of Intellectual Property (IP) and Intellectual Property Rights (IPR). It also discusses the significance of intellectual property rights in the realm of biotechnology. The current thesis is likewise concerned with our country's encounter with the traditional knowledge domain. This thesis also claims that stringent patent rights has harmed indigenous peoples and their conventional medical knowledge. It also analyses instances in which it is being repeatedly demonstrated that the present patent instrument does not give indigenous people with a free hand. It suggests that the development and distribution of protocols fostered by Indian regulatory structure is insufficient as a legal weapon for the safeguard of traditional healthcare knowledge. The thesis investigates India's duty to conserve and maintain traditional medical knowledge, and also model recommendations for pharmaceutical industry to use traditional herbal expertise. In previous years, there has been a lot of discussion on the link between international organizations governing intellectual property, traditional knowledge, and ecological diversity. The preservation of traditional knowledge (TK) stands out as a key difficulty among the many complicated and contentious topics in modern international legal debate on this subject. This dissertation arose from significant doubts over how Indigenous Intellectual Property and Traditional Knowledge could be handled responsibly, and it also examines existing methods of safeguarding. It emphasizes on how Native Intellectual Property and Cultural Heritage must be managed morally, judicially, and constitutionally in general public realm and certain other aspects of public utilization.