In India, malaria is endemic in all areas, and it has emerged as a major health problem in many of the small, medium and metropolitan towns and cities. These regions are malaria prone, not only because of the prevalence of appropriate climatic conditions, but also because of either the presence of vegetation (forests), irrigated agriculture practices, or due to rampant urbanization leading to change in land use. This study focuses on the state of Delhi, where though the level of malaria incidence with respect to the malaria prone regions of the country is not high, however, continuous influx of population into the peri-urban areas without adequate civic facilities, has led to generation of conditions of breeding for the malaria parasite and hence the prevalence of the disease. The presence of stretches of forest areas, water bodies also contribute to the occurrence of malaria even in the most developed areas of Delhi. In this study, the transmission window for malaria has been determined for the current climate variability and an attempt has been made to understand the malarial determinants that dominate in the transmission of malaria in each of the districts/wards of Delhi. The parameters thus identified can be managed for adapting to the current climate variability and hence climate change in the future.