ANNOUNCEMENTS
Nano Carbon Materials [Fullerene C60, Single Walled Carbon Nanotubes (SWCNTs), Reduced Graphene Oxide (rGO)] along with their unusual structures show interesting intrinsic properties with applications in diverse fields of science. These materials have been recognized with two Nobel Prizes in 1985, 2010 respectively. Attaining the true potential of these materials has been hampered due to less or no solubility in common solvents.
SWCNT and rGO have been made water soluble by thermolysis with the aryl azide “Azido-m-meconine”, followed by mild oxidation without using any harsh step. These Functionalized nano carbon derivatives have been characterized by using spectroscopic and microscopic techniques. In this thesis the use of new water-soluble SWCNT –Mn (II) complex and water soluble rGO-Mn (II) complexes have been used to study their effects on the model plant Arabidopsis thaliana. Greenhouse experiments on the tomato plant with rGO-Mn (II) Complex show significant growth promoting activity. The potential anti-cancer activity of rGO–Mn (II) complex has been evaluated using U937, CT26, 4T1 cell lines.
“Fullarazir” obtained from “Fullarazirman” by removal of Mn, has been esterified with 4 Butyne-1-ol. This material has been conjugated with an aryl azido derivative of Doxorubicin, (a most commonly used anti-cancer drug) using classical “Click” Chemistry to successful synthesis of Nano Carbon Drug Conjugate (NCDC). Trastuzumab, a monoclonal antibody has been incubated with BCN-NHS Ester and then conjugation with an aryl azide based derivative of Doxorubicin to yield the Antibody Drug Conjugate (ADC). This synthesis used a modern version of “Click” reaction i. e. the Strain Promoted Alkyne Azide Coupling (SPAAC) reaction. The “Click” and “Bio-orthogonal” chemistry have been recognized by the award of the Nobel Prize in Chemistry 2022. These new nano-conjugate has been characterized using different spectroscopic techniques and its potential anti-cancer activity has also been evaluated.
These studies thus, demonstrate that SWCNT and rGO have been made water soluble and potential uses in agriculture and as anti-cancer agent has been demonstrated.
